The Heparin Cofactor II (HRP) (HCII) Antibody from MyBioSource.com is a Goat Polyclonal antibody to heparin cofactor II, and SERPIND1. This antibody recognizes Human, Mouse, Rat, Canine, Porcine, and Rabbit antigen. The Heparin Cofactor II (HRP) (HCII) Antibody has been validated for the following applications: ELISA.
Description
Heparin Cofactor II (HCII) is a single chain glycoprotein produced in the liver and circulates in plasma at concentration of 50-100ug/ml (0.8-1.5uM). A member of the SERPIN family of proteinase inhibitors, HCII exhibits a relatively narrow specificity and is only known to inhibit the serine proteinases thrombin and chymotrypsin. The inhibitory activity toward thrombin is accelerated up to 1000-fold in the presence of optimal concentrations of heparin. Unlike Antithrombin, thrombin inhibition by HCII is also enhanced by dermatan sulphate. HCII has an apparent molecular weight of 65,600 daltons and interaction with thrombin results in a covalent 1:1 enzyme-inhibitor complex of 102,600 daltons (1-3)